Buffalo Bills at Los Angeles Rams
The Line
Bills +3.5, Rams -3.5, total 54.5, moneyline Bills +150, Rams -180 (DraftKings; captured Oct 12, 2026 at 7:00 AM EDT).
Weather
This game is played indoors, so conditions are not a factor.
Series History
| Date | Opponent | Score | Result |
|---|---|---|---|
| 2024-12-08 | at LA | 42-44 | L |
| 2022-09-08 | at LA | 31-10 | W |
| 2020-09-27 | vs. LA | 35-32 | W |
| 2016-10-09 | at LA | 30-19 | W |
Team Form – 2026 Season – Through Week 5
| Bills | Rams | |
|---|---|---|
| Offense | ||
| Passing yards | 1039 (21st) | 1202 (12th) |
| Passing touchdowns | 6 (20th) | 6 (23rd) |
| Interceptions thrown | 3 (11th) | 6 (29th) |
| Rushing yards | 556 (14th) | 507 (17th) |
| Rushing touchdowns | 10 (1st) | 4 (16th) |
| Receiving first downs | 46 (21st) | 56 (14th) |
| Sacks allowed | 9 (7th) | 6 (5th) |
| Fumbles lost | 4 (21st) | 2 (12th) |
| Passing expected points added | 33.9 (8th) | 13.6 (14th) |
| Rushing expected points added | 12.1 (3rd) | -7.2 (18th) |
| Defense | ||
| Sacks recorded | 10.0 (19th) | 7.0 (27th) |
| Interceptions made | 2 (25th) | 3 (19th) |
| Tackles for loss | 20 (19th) | 10 (32nd) |
| Discipline | ||
| Penalties | 30 (3rd) | 31 (7th) |
| Penalty yards | 250 (10th) | 284 (16th) |
Head-to-Head Trends
- Record: the Bills are 3-1 in the last 4 meetings
- Against the spread: 3-1 in 4 rated games
- Over/under: 3 over, 1 under in 4 rated games
- Scoring: 34.5 points per game, 26.2 allowed
Practice report
No game-status designations (Out, Doubtful, Questionable) have been published for this game yet. These are practice participation levels from the official report.
Buffalo Bills
- Ed Oliver — Did Not Participate In Practice (Knee)
- Jordan Hancock — Did Not Participate In Practice (Hamstring)
- Josh Palmer — Did Not Participate In Practice (Shoulder)
- T.J. Sanders — Did Not Participate In Practice (Illness)
- T.J. Sanders — Limited Participation in Practice (Illness)
- Ar'maj Reed-Adams — Limited Participation in Practice (Elbow)
- Christian Benford — Did Not Participate In Practice (Toe)
- Cole Bishop — Limited Participation in Practice (Knee)
- DJ Moore — Limited Participation in Practice (Shoulder)
- DJ Moore — Limited Participation in Practice (Shoulder)
- Dee Alford — Limited Participation in Practice (Ankle)
- Ed Oliver — Full Participation in Practice (Hip)
- Jordan Hancock — Full Participation in Practice (Quadricep)
- Keon Coleman — Limited Participation in Practice (Ankle)
- Landon Jackson — Full Participation in Practice (Knee)
- Ray Davis — Limited Participation in Practice (Hamstring)
- T.J. Sanders — Limited Participation in Practice (Knee)
- T.J. Sanders — Limited Participation in Practice (Knee)
- Ty Johnson — Limited Participation in Practice (Hamstring)
- Ty Johnson — Limited Participation in Practice (Hamstring)
- Ar'maj Reed-Adams — Full Participation in Practice (Elbow)
- Ar'maj Reed-Adams — Full Participation in Practice (Elbow)
- Bradley Chubb — Full Participation in Practice (Thumb)
- Bradley Chubb — Full Participation in Practice (Thumb)
- Bradley Chubb — Full Participation in Practice (Thumb)
- Bradley Chubb — Full Participation in Practice (Thumb)
- Christian Benford — Full Participation in Practice (Toe)
- DJ Moore — Limited Participation in Practice (Shoulder)
- Damar Hamlin — Limited Participation in Practice (Ribs)
- Damar Hamlin — Full Participation in Practice (Rib)
- Deone Walker — Full Participation in Practice (Quadricep)
- Dorian Williams — Full Participation in Practice (Hip)
- Dorian Williams — Full Participation in Practice (Hip)
- Joe Andreessen — Full Participation in Practice (Knee)
- Joe Andreessen — Full Participation in Practice (Knee)
- Joe Andreessen — Full Participation in Practice (Knee)
- Jordan Hancock — Full Participation in Practice (Quadricep)
- Keon Coleman — Limited Participation in Practice (Ankle)
- Keon Coleman — Full Participation in Practice (Ankle)
- Ray Davis — Full Participation in Practice (Hamstring)
- Sam Franklin Jr. — Did Not Participate In Practice (Not injury related – personal matter)
- T.J. Sanders — Full Participation in Practice (Illness)
- Terrel Bernard — Limited Participation in Practice (Calf)
- Terrel Bernard — Did Not Participate In Practice (Knee)
- Terrel Bernard — Did Not Participate In Practice (Knee)
- Terrel Bernard — Did Not Participate In Practice (Knee)
- Ty Johnson — Full Participation in Practice (Hamstring)
Los Angeles Rams
- Aaron Donald — Did Not Participate In Practice (Not injury related – resting player)
- Aaron Donald — Did Not Participate In Practice (Back)
- Jaylen Watson — Did Not Participate In Practice (Shoulder)
- Kamren Kinchens — Did Not Participate In Practice (Hamstring)
- Terrance Ferguson — Did Not Participate In Practice (Ankle)
- Jordan Whittington — Did Not Participate In Practice (Quadricep)
- Kamren Kinchens — Did Not Participate In Practice (Hamstring)
- Puka Nacua — Did Not Participate In Practice (Hip)
- Colby Parkinson — Did Not Participate In Practice (Knee)
- Colby Parkinson — Did Not Participate In Practice (Knee)
- Josaiah Stewart — Did Not Participate In Practice (Groin)
- Puka Nacua — Did Not Participate In Practice (Hip)
- Quentin Lake — Limited Participation in Practice (Hip)
- Aaron Donald — Did Not Participate In Practice (Not injury related – resting player)
- Aaron Donald — Did Not Participate In Practice (Not injury related – resting player)
- Aaron Donald — Did Not Participate In Practice (Back)
- Alaric Jackson — Full Participation in Practice (Not injury related – resting player)
- Alaric Jackson — Did Not Participate In Practice (Not injury related – resting player)
- Alaric Jackson — Full Participation in Practice (Knee)
- Alaric Jackson — Did Not Participate In Practice (Not injury related – resting player)
- Alaric Jackson — Did Not Participate In Practice (Not injury related – resting player)
- Byron Young — Full Participation in Practice (Not injury related – resting player)
- Byron Young — Did Not Participate In Practice (Not injury related – resting player)
- Byron Young — Did Not Participate In Practice (Not injury related – resting player)
- Byron Young — Did Not Participate In Practice (Not injury related – resting player)
- Byron Young — Did Not Participate In Practice (Not injury related – resting player)
- Colby Parkinson — Full Participation in Practice (Knee)
- Davante Adams — Full Participation in Practice (Not injury related – resting player)
- Davante Adams — Full Participation in Practice (Not injury related – resting player)
- Davante Adams — Full Participation in Practice (Not injury related – resting player)
- Grant Stuard — Full Participation in Practice (Hamstring)
- Grant Stuard — Limited Participation in Practice (Hamstring)
- Jaylen Watson — Full Participation in Practice (Toe)
- Jaylen Watson — Full Participation in Practice (Shoulder)
- Jordan Whittington — Full Participation in Practice (Quadricep)
- Josaiah Stewart — Limited Participation in Practice (Groin)
- Josh Wallace — Full Participation in Practice (Shoulder)
- Kam Curl — Limited Participation in Practice (Ankle)
- Kamren Kinchens — Full Participation in Practice (Hamstring)
- Konata Mumpfield — Full Participation in Practice (Shoulder)
- Myles Garrett — Full Participation in Practice (Knee)
- Nate Landman — Limited Participation in Practice (Shoulder)
- Nate Landman — Limited Participation in Practice (Shoulder)
- Nate Landman — Full Participation in Practice (Shoulder)
- Nate Landman — Full Participation in Practice (Shoulder)
- Omar Speights — Full Participation in Practice (Hip)
- Poona Ford — Full Participation in Practice (Not injury related – resting player)
- Puka Nacua — Full Participation in Practice (Hip)
- Quentin Lake — Full Participation in Practice (Shoulder)
- Terrance Ferguson — Full Participation in Practice (Ankle)
- Tyler Higbee — Full Participation in Practice (Not injury related – resting player)
- Tyler Higbee — Did Not Participate In Practice (Not injury related – resting player)
- Tyler Higbee — Did Not Participate In Practice (Not injury related – resting player)
- Tyler Higbee — Did Not Participate In Practice (Not injury related – resting player)