Detroit Lions at Buffalo Bills
The Line
Lions +5.5, Bills -5.5, total 54.5 (DraftKings; captured Sep 17, 2026 at 6:00 AM EDT).
Weather
Conditions: Overcast; Temperature: 66°F; Wind: 4 mph, gusting to 4 mph; Chance of precipitation: 2%
Series History
| Date | Opponent | Score | Result |
|---|---|---|---|
| 2024-12-15 | vs. BUF | 42-48 | L |
| 2022-11-24 | vs. BUF | 25-28 | L |
| 2018-12-16 | at BUF | 13-14 | L |
| 2014-10-05 | vs. BUF | 14-17 | L |
| 2010-11-14 | at BUF | 12-14 | L |
| 2006-10-15 | vs. BUF | 20-17 | W |
| 2002-10-27 | at BUF | 17-24 | L |
Team Form – 2026 Season – Through Week 1
| Lions | Bills | |
|---|---|---|
| Offense | ||
| Passing yards | 206 (17th) | 334 (4th) |
| Passing touchdowns | 2 (12th) | 2 (9th) |
| Interceptions thrown | 0 (5th) | 0 (3rd) |
| Rushing yards | 165 (5th) | 86 (25th) |
| Rushing touchdowns | 2 (5th) | 2 (3rd) |
| Receiving first downs | 10 (15th) | 13 (7th) |
| Sacks allowed | 1 (8th) | 2 (12th) |
| Fumbles lost | 1 (20th) | 0 (3rd) |
| Passing expected points added | 5.9 (10th) | 14.5 (5th) |
| Rushing expected points added | -0.7 (16th) | -2.6 (26th) |
| Defense | ||
| Sacks recorded | 5.0 (1st) | 3.0 (8th) |
| Interceptions made | 2 (2nd) | 0 (19th) |
| Tackles for loss | 7 (4th) | 8 (3rd) |
| Discipline | ||
| Penalties | 8 (19th) | 10 (26th) |
| Penalty yards | 61 (19th) | 85 (24th) |
Head-to-Head Trends
- Record: the Lions are 1-6 in the last 7 meetings
- Against the spread: 4-3 in 7 rated games
- Over/under: 1 over, 6 under in 7 rated games
- Scoring: 20.4 points per game, 23.1 allowed
Practice report
No game-status designations (Out, Doubtful, Questionable) have been published for this game yet. These are practice participation levels from the official report.
Detroit Lions
- Blake Miller — Did Not Participate In Practice (Knee)
- Christian Mahogany — Did Not Participate In Practice (Hip)
- Christian Izien — Limited Participation in Practice (Groin)
- D.J. Reed — Limited Participation in Practice (Foot)
- Christian Izien — Full Participation in Practice (Groin)
- Derrick Moore — Full Participation in Practice (Hamstring)
- Ennis Rakestraw Jr. — Full Participation in Practice (Ankle)
- Jimmy Rolder — Full Participation in Practice (Hamstring)
- Juice Scruggs — Full Participation in Practice (Knee)
- Keith Abney II — Full Participation in Practice (Hand)
- Mekhi Wingo — Full Participation in Practice (Groin)
- Thomas Harper — Full Participation in Practice (Ankle)
- Trevor Nowaske — Full Participation in Practice (Knee)
Buffalo Bills
- Cole Bishop — Limited Participation in Practice (Knee)
- Jordan Hancock — Full Participation in Practice (Quadricep)
- T.J. Sanders — Limited Participation in Practice (Knee)
- T.J. Sanders — Limited Participation in Practice (Knee)
- Ty Johnson — Limited Participation in Practice (Hamstring)
- Ty Johnson — Limited Participation in Practice (Hamstring)
- Bradley Chubb — Full Participation in Practice (Thumb)
- Jordan Hancock — Full Participation in Practice (Quadricep)
- Terrel Bernard — Limited Participation in Practice (Calf)