San Francisco 49ers at Los Angeles Rams
The Line
49ers +3.5, Rams -3.5, total 48.5 (DraftKings; captured Sep 10, 2026 at 6:00 AM EDT).
Weather
Conditions: Overcast; Temperature: 54°F; Wind: 1 mph, gusting to 7 mph; Chance of precipitation: 0%
Series History
| Date | Opponent | Score | Result |
|---|---|---|---|
| 2025-11-09 | vs. LA | 26-42 | L |
| 2025-10-02 | at LA | 26-23 | W |
| 2024-12-12 | vs. LA | 6-12 | L |
| 2024-09-22 | at LA | 24-27 | L |
| 2024-01-07 | vs. LA | 20-21 | L |
| 2023-09-17 | at LA | 30-23 | W |
| 2022-10-30 | at LA | 31-14 | W |
| 2022-10-03 | vs. LA | 24-9 | W |
| 2022-01-30 | at LA | 17-20 | L |
| 2022-01-09 | at LA | 27-24 | W |
| 2021-11-15 | vs. LA | 31-10 | W |
| 2020-11-29 | at LA | 23-20 | W |
| 2020-10-18 | vs. LA | 24-16 | W |
| 2019-12-21 | vs. LA | 34-31 | W |
| 2019-10-13 | at LA | 20-7 | W |
| 2018-12-30 | at LA | 32-48 | L |
| 2018-10-21 | vs. LA | 10-39 | L |
| 2017-12-31 | at LA | 34-13 | W |
| 2017-09-21 | vs. LA | 39-41 | L |
| 2016-12-24 | at LA | 22-21 | W |
Head-to-Head Trends
- Record: the 49ers are 5-5 in the last 10 meetings
- Against the spread: 5-5 in 10 rated games
- Over/under: 7 over, 3 under in 10 rated games
- Scoring: 23.1 points per game, 21.5 allowed
Practice report
No game-status designations (Out, Doubtful, Questionable) have been published for this game yet. These are practice participation levels from the official report.
San Francisco 49ers
- Alfred Collins — Limited Participation in Practice (Knee)
- Dre Greenlaw — Limited Participation in Practice (Achilles)
- George Kittle — Limited Participation in Practice (Achilles)
- Gracen Halton — Limited Participation in Practice (Ankle)
- James Thompson Jr. — Did Not Participate In Practice (Hamstring)
- Kyle Juszczyk — Limited Participation in Practice (Finger)
- Luke Gifford — Limited Participation in Practice (Hamstring)
- Nick Bosa — Limited Participation in Practice (Knee)
- Renardo Green — Limited Participation in Practice (Hamstring)
- Romello Height — Limited Participation in Practice (Ankle)
- Upton Stout — Full Participation in Practice (Achilles)
Los Angeles Rams
- Aaron Donald — Limited Participation in Practice (Not injury related – resting player)
- Alaric Jackson — Did Not Participate In Practice (Not injury related – resting player)
- Byron Young — Did Not Participate In Practice (Not injury related – resting player)
- Grant Stuard — Limited Participation in Practice (Hamstring)
- Jaylen Watson — Did Not Participate In Practice (Toe)
- Myles Garrett — Did Not Participate In Practice (Knee)
- Tyler Higbee — Did Not Participate In Practice (Not injury related – resting player)